Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug

Polymers in tune. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad‐spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching that of the pristine drug and at the same time sup...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Advanced healthcare materials 2014-09, Vol.3 (9), p.1404-1407
Hauptverfasser:	Smith, Anton A. A., Wohl, Benjamin M., Kryger, Mille B. L., Hedemann, Natasha, Guerrero-Sanchez, Carlos, Postma, Almar, Zelikin, Alexander N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cell Line Chemical compounds Chromatography, Gel Conjugates drug delivery Drug Discovery Drugs Effectiveness Health care high throughput screening inflammation Macrophages - drug effects Macrophages - metabolism Magnetic Resonance Spectroscopy Medical sciences Mice Molecular Weight Nitric Oxide - analysis Nitric Oxide - metabolism Origins Polymers prodrugs Prodrugs - chemistry Prodrugs - pharmacology Ribavirin - chemistry Ribavirin - pharmacology Side effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Polymers in tune. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad‐spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching that of the pristine drug and at the same time suppressed the origin of the main side effect of ribavirin.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201300637