Application of surface enhanced Raman scattering to the solution based detection of a popular legal high, 5,6-methylenedioxy-2-aminoindane (MDAI)

The ever increasing numbers and users of designer drugs means that analytical techniques have to evolve constantly to facilitate their identification and detection. We report that surface enhanced Raman scattering (SERS) offers a relatively fast and inexpensive method for the detection of MDAI at lo...

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Veröffentlicht in:	Analyst (London) 2015-07, Vol.140 (13), p.4399-4406
Hauptverfasser:	Mabbott, Samuel, Alharbi, Omar, Groves, Kate, Goodacre, Royston
Format:	Artikel
Sprache:	eng
Schlagworte:	Acceptability Drug Contamination Drugs Indans - analysis Indans - chemistry Legal Limit of Detection Low concentrations Mathematical analysis Optimization Raman scattering Silver Solutions - analysis Solutions - chemistry Spectrum Analysis, Raman - methods
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Beschreibung
Zusammenfassung:	The ever increasing numbers and users of designer drugs means that analytical techniques have to evolve constantly to facilitate their identification and detection. We report that surface enhanced Raman scattering (SERS) offers a relatively fast and inexpensive method for the detection of MDAI at low concentrations. Careful optimisation of the silver sol, and salt concentrations was undertaken to ensure the SERS analysis was both reproducible and sensitive. The optimised system demonstrated acceptable peak variations of less than 15% RSD and resulted in a detection limit of just 8 ppm (5.4 × 10(-5) M).
ISSN:	0003-2654 1364-5528
DOI:	10.1039/c5an00591d