Metal-Free Oxidative Decarbonylative Coupling of Aliphatic Aldehydes with Azaarenes: Successful Minisci-Type Alkylation of Various Heterocycles

Metal-Free Oxidative Decarbonylative Coupling of Aliphatic Aldehydes with Azaarenes: Successful Minisci-Type Alkylation of Various Heterocycles

A metal‐free oxidative decarbonylative coupling of aliphatic aldehydes with various electron‐deficient heterocycles has been developed. This reaction is supposed to be realized via a Minisci‐type mechanism, based on the substrate scope, regioselectivity and radical trapping experiments. The ready av...

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Veröffentlicht in:Advanced synthesis & catalysis 2015-06, Vol.357 (9), p.2055-2060
Hauptverfasser: Tang, Ren-Jin, Kang, Lei, Yang, Luo
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Aliphatic compounds
Alkylation
Availability
Biocompatibility
decarbonylation
heterocycles
Joining
metal-free conditions
Radicals
Synthesis
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Zusammenfassung:A metal‐free oxidative decarbonylative coupling of aliphatic aldehydes with various electron‐deficient heterocycles has been developed. This reaction is supposed to be realized via a Minisci‐type mechanism, based on the substrate scope, regioselectivity and radical trapping experiments. The ready availability of aliphatic aldehydes, metal‐free conditions and broad substrate scope should make this method attractive for the late‐stage alkylation of bioactive heterocycles.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201500268