Gold Nanoparticles Displaying Tumor-Associated Self-Antigens as a Potential Vaccine for Cancer Immunotherapy

Gold Nanoparticles Displaying Tumor-Associated Self-Antigens as a Potential Vaccine for Cancer Immunotherapy

Golden vaccine for cancers. Gold nanoparticles enable efficient antigen delivery to dendritic cells and then activate the cells to facilitate cross‐presentation, inducing antigen‐specific cytotoxic T‐lymphocyte responses for effective cancer therapy.

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Bibliographische Detailangaben
Veröffentlicht in:Advanced healthcare materials 2014-08, Vol.3 (8), p.1194-1199
Hauptverfasser: Ahn, Sukyung, Lee, In-Hyun, Kang, Sukmo, Kim, Daejin, Choi, Minsuk, Saw, Phei Er, Shin, Eui-Cheol, Jon, Sangyong
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antigens
Antigens, Neoplasm - administration & dosage
Antigens, Neoplasm - chemistry
Cancer
cancer vaccines
Cancer Vaccines - immunology
Cell Line
Dendritic Cells - immunology
Dendritic Cells - metabolism
extra domain B
Fibronectins - administration & dosage
Fibronectins - chemistry
Gold
Gold - chemistry
gold nanoparticles
Health care
Immunotherapy
Interferon-gamma - metabolism
Interleukin-2 - metabolism
Metal Nanoparticles - chemistry
Mice
Mice, Inbred BALB C
Nanoparticles
Neoplasms - therapy
Ovalbumin - chemistry
Ovalbumin - immunology
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Cytotoxic - metabolism
Therapy
tumor-associated antigens
Vaccines
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Beschreibung
Zusammenfassung:Golden vaccine for cancers. Gold nanoparticles enable efficient antigen delivery to dendritic cells and then activate the cells to facilitate cross‐presentation, inducing antigen‐specific cytotoxic T‐lymphocyte responses for effective cancer therapy.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201300597