CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines

Self‐adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor‐associated MUC1‐glycopeptide B‐cell epitope and tetanus toxin T‐cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll‐like recept...

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Veröffentlicht in:	Advanced healthcare materials 2015-03, Vol.4 (4), p.522-527
Hauptverfasser:	Hartmann, Sebastian, Nuhn, Lutz, Palitzsch, Björn, Glaffig, Markus, Stergiou, Natascha, Gerlitzki, Bastian, Schmitt, Edgar, Kunz, Horst, Zentel, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Amino Acid Sequence Animals anti-tumor vaccines Cancer Vaccines - immunology Cationic cationic nanohydrogels Cations Complexation Conjugates CpG codelivery Enzyme-Linked Immunosorbent Assay Glycopeptides Glycopeptides - chemistry Glycopeptides - immunology Humans Hydrogel, Polyethylene Glycol Dimethacrylate - chemical synthesis Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Immune systems Mice, Inbred BALB C Molecular Sequence Data MUC1 glycopeptide Nanoparticles - chemistry Nanoparticles - ultrastructure Nanostructure Oligodeoxyribonucleotides - chemistry Oligonucleotides self-adjuvanting vaccines Vaccines
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Beschreibung
Zusammenfassung:	Self‐adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor‐associated MUC1‐glycopeptide B‐cell epitope and tetanus toxin T‐cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll‐like receptor (TLR) stimulated T‐cell proliferation and rapid immune activation. This co‐delivery promotes induction of specific MUC1‐antibodies binding to human breast tumor cells without external adjuvant.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201400460