Comparison of Laparoscopic Myomectomy in Large Myomas With and Without Leuprolide Acetate

Abstract Study Objective To evaluate the efficacy of gonadotropin-releasing hormone analogue (GnRHa) use before laparoscopic myomectomy (LM) in large myomas. Design Prospective study (Canadian Task Force classification II-1). Setting University-affiliated hospital. Patients Ninety-one women with large myomas (≥10 cm) or more than 2 myomas ≥ 5 cm underwent LM between July 2011 and March 2014. Interventions Forty patients underwent LM after GnRHa use (group A) and 51 underwent LM only (group B). GnRHa was used for 3 doses every 4 weeks before LM in group A. Measurements and Main Results Group A had a significantly smaller maximum diameter of the largest myoma than group B (8.5 ± 2.1 vs 10.7 ± 2.4, p