In vivovisible light-triggered drug release from an implanted depot

Controlling chemistry in space and time has offered scientists and engineers powerful tools for research and technology. For example, on-demand photo-triggered activation of neurotransmitters has revolutionized neuroscience. Non-invasive control of the availability of bioactive molecules in living o...

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Veröffentlicht in:Chemical science (Cambridge) 2014-12, Vol.6 (1), p.335-341
Hauptverfasser: Carling, Carl-Johan, Viger, Mathieu L, Nguyen Huu, Viet Anh, Garcia, Arnold V, Almutairi, Adah
Format: Artikel
Sprache:eng
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Zusammenfassung:Controlling chemistry in space and time has offered scientists and engineers powerful tools for research and technology. For example, on-demand photo-triggered activation of neurotransmitters has revolutionized neuroscience. Non-invasive control of the availability of bioactive molecules in living organisms will undoubtedly lead to major advances; however, this requires the development of photosystems that efficiently respond to regions of the electromagnetic spectrum that innocuously penetrate tissue. To this end, we have developed a polymer that photochemically degrades upon absorption of one photon of visible light and demonstrated its potential for medical applications. Particles formulated from this polymer release molecular cargo in vitroand in vivoupon irradiation with blue visible light through a photoexpansile swelling mechanism.
ISSN:2041-6520
2041-6539
DOI:10.1039/c4sc02651a