Prodrug-based nanoparticulate drug delivery strategies for cancer therapy

Highlights • Recent trends in prodrug-based nanocarriers for cancer therapy are provided. • Stimuli-sensitive nanoparticulate drug delivery systems (Nano-DDS) facilitates the spatio-temporally controlled release of drugs. • Hybrid Nano-DDS is a potent multifunctional platform to deliver anticancer d...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2014-11, Vol.35 (11), p.556-566
Hauptverfasser:	Luo, Cong, Sun, Jin, Sun, Bingjun, He, Zhonggui
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry cancer therapy combination therapy Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Delivery Systems - methods Humans hybrid nanoassemblies Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasms - drug therapy prodrug nanoassemblies Prodrugs - administration & dosage Prodrugs - chemistry stimuli-responsive
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Beschreibung
Zusammenfassung:	Highlights • Recent trends in prodrug-based nanocarriers for cancer therapy are provided. • Stimuli-sensitive nanoparticulate drug delivery systems (Nano-DDS) facilitates the spatio-temporally controlled release of drugs. • Hybrid Nano-DDS is a potent multifunctional platform to deliver anticancer drugs. • Combination therapy can improve the therapeutic effects of prodrug-based Nano-DDS.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2014.09.008