Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPARγ agonist in vitro and in MPTP-treated mice

Highlights • MDG548 is a novel highly selective PPAR-gamma agonist. • MDG548 is protective against H2 O2 and MPP+ in cultured neurons. • MDG548 inhibits NF-kB activation in vitro. • MDG548 is neuroprotective in a MPTP model of PD. • MDG548 counteracts microglia reactivity and iNOS in the MPTP model....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-08, Vol.302, p.23-35
Hauptverfasser:	Lecca, D, Nevin, D.K, Mulas, G, Casu, M.A, Diana, A, Rossi, D, Sacchetti, G, Carta, A.R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Animals, Newborn Cells, Cultured Cerebral Cortex - cytology Disease Models, Animal Encephalitis - drug therapy Encephalitis - etiology Humans Hydrogen Peroxide - adverse effects Hypoglycemic Agents - pharmacology Lipopolysaccharides - pharmacology Male Mice, Inbred C57BL microglia MPTP neuroinflammation Neurology Neurons - drug effects Neuroprotective Agents - therapeutic use Neurotoxins - pharmacology NF-kappa B - metabolism Parkinson Parkinsonian Disorders - chemically induced Parkinsonian Disorders - complications Parkinsonian Disorders - pathology PPAR Rats Rats, Wistar Salmonella typhimurium Thiazolidinediones - pharmacology Thiobarbiturates - therapeutic use Tyrosine 3-Monooxygenase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • MDG548 is a novel highly selective PPAR-gamma agonist. • MDG548 is protective against H2 O2 and MPP+ in cultured neurons. • MDG548 inhibits NF-kB activation in vitro. • MDG548 is neuroprotective in a MPTP model of PD. • MDG548 counteracts microglia reactivity and iNOS in the MPTP model.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.04.026