Intranasal administration of glial-derived neurotrophic factor (GDNF) rapidly and significantly increases whole-brain GDNF level in rats

Highlights • Intranasal GDNF rapidly enters the rat brain. • Intranasally administered GDNF significantly increases brain GDNF levels. • Intranasally administered GDNF distributes along the rostral-caudal axis of the rat brain. • Intranasal GDNF may provide a non-invasive treatment for early stage P...

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Veröffentlicht in:	Neuroscience 2015-09, Vol.303, p.569-576
Hauptverfasser:	Bender, T.S, Migliore, M.M, Campbell, R.B, John Gatley, S, Waszczak, B.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Analysis of Variance Animals Autoradiography Brain - drug effects Brain - metabolism Dose-Response Relationship, Drug Drug Delivery Systems Enzyme-Linked Immunosorbent Assay Glial Cell Line-Derived Neurotrophic Factor - administration & dosage Glial Cell Line-Derived Neurotrophic Factor - metabolism glial cell-line derived neurotrophic factor (GDNF) intranasal Iodine Isotopes - pharmacokinetics liposomes Male Neurology neuroprotection Parkinson’s disease Rats Rats, Sprague-Dawley Time Factors
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Zusammenfassung:	Highlights • Intranasal GDNF rapidly enters the rat brain. • Intranasally administered GDNF significantly increases brain GDNF levels. • Intranasally administered GDNF distributes along the rostral-caudal axis of the rat brain. • Intranasal GDNF may provide a non-invasive treatment for early stage PD.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.07.016