Effects of interleukin-2 on bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching

Highlights • IL-2 induce frequent rhythm patterns followed by smooth transient fragments of paroxysmal tachyarrhythmia. • In the presence of IL-2, stretching of the tissue led to appearance of abnormal bio-electrical activity, predominantly in the lengthening of APD90. • There is a link between the...

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Veröffentlicht in:	Immunology letters 2015-09, Vol.167 (1), p.23-28
Hauptverfasser:	Aksyonov, A, Mitrokhin, V.M, Mladenov, M.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - drug effects Allergy and Immunology Animals Atrial Function - drug effects Atrial Function - physiology Atrium Electrophysiological Phenomena - drug effects Heart Interleukin 2 Interleukin-2 - pharmacology Male Muscle Contraction Myocardium - metabolism Myocytes, Cardiac - drug effects Rats Stretch Tachycardia
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Zusammenfassung:	Highlights • IL-2 induce frequent rhythm patterns followed by smooth transient fragments of paroxysmal tachyarrhythmia. • In the presence of IL-2, stretching of the tissue led to appearance of abnormal bio-electrical activity, predominantly in the lengthening of APD90. • There is a link between the IL-2 and stretch induced mechanisms.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.06.009