Anxiogenic drug administration and elevated plus-maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus

Highlights • Anxiogenic stimuli activate serotonergic neurons in the dorsal raphe nucleus and relaxin-3 neurons in the nucleus incertus. • Activation of relaxin-3 neurons in the nucleus incertus is associated with changes in anxiety-like behavior. • These findings support a role for the interaction...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-09, Vol.303, p.270-284
Hauptverfasser:	Lawther, A.J, Clissold, M.L, Ma, S, Kent, S, Lowry, C.A, Gundlach, A.L, Hale, M.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology anxiety Carbolines - pharmacology Cell Count dorsal raphe nucleus Dorsal Raphe Nucleus - cytology Dose-Response Relationship, Drug elevated plus-maze Male Maze Learning - drug effects Neurology Neurons - drug effects Neurons - metabolism nucleus incertus Proto-Oncogene Proteins c-fos - metabolism Raphe Nuclei - cytology Rats Rats, Wistar Relaxin - metabolism relaxin-3 serotonin Serotonin - metabolism Time Factors Tryptophan Hydroxylase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Anxiogenic stimuli activate serotonergic neurons in the dorsal raphe nucleus and relaxin-3 neurons in the nucleus incertus. • Activation of relaxin-3 neurons in the nucleus incertus is associated with changes in anxiety-like behavior. • These findings support a role for the interaction of relaxin-3 and serotonergic systems in the control of anxiety.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.06.052