Phosphorylated alpha-enolase induces autoantibodies in HLA-DR8 pancreatic cancer patients and triggers HLA-DR8 restricted T-cell activation
Highlights • In pancreatic ductal adenocarcinoma the glycolytic enzyme ENOA is upregulated. • Up-regulation elicits the production of ENOA1,2 autoantibodies. • HLA-DRB1*08 allele is more frequent in PDAC patients with autoantibodies. • P-ENOA peptide binds HLA-DR8 antigen and activates specific CD4+...
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| Veröffentlicht in: | Immunology letters 2015-09, Vol.167 (1), p.11-16 |
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| container_title | Immunology letters |
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| creator | Capello, Michela Caorsi, Cristiana Bogantes Hernandez, Pablo Josè Dametto, Ennia Bertinetto, Francesca Eleonora Magistroni, Paola Rendine, Sabina Amoroso, Antonio Novelli, Francesco |
| description | Highlights • In pancreatic ductal adenocarcinoma the glycolytic enzyme ENOA is upregulated. • Up-regulation elicits the production of ENOA1,2 autoantibodies. • HLA-DRB1*08 allele is more frequent in PDAC patients with autoantibodies. • P-ENOA peptide binds HLA-DR8 antigen and activates specific CD4+ T cell clones. |
| doi_str_mv | 10.1016/j.imlet.2015.06.008 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-a3e3c3660fc8fa388132c5fd01a1922293e80bdc200c0ce12a8a2d91daa1d5463</citedby><cites>FETCH-LOGICAL-c492t-a3e3c3660fc8fa388132c5fd01a1922293e80bdc200c0ce12a8a2d91daa1d5463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.imlet.2015.06.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26096821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capello, Michela</creatorcontrib><creatorcontrib>Caorsi, Cristiana</creatorcontrib><creatorcontrib>Bogantes Hernandez, Pablo Josè</creatorcontrib><creatorcontrib>Dametto, Ennia</creatorcontrib><creatorcontrib>Bertinetto, Francesca Eleonora</creatorcontrib><creatorcontrib>Magistroni, Paola</creatorcontrib><creatorcontrib>Rendine, Sabina</creatorcontrib><creatorcontrib>Amoroso, Antonio</creatorcontrib><creatorcontrib>Novelli, Francesco</creatorcontrib><title>Phosphorylated alpha-enolase induces autoantibodies in HLA-DR8 pancreatic cancer patients and triggers HLA-DR8 restricted T-cell activation</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Highlights • In pancreatic ductal adenocarcinoma the glycolytic enzyme ENOA is upregulated. • Up-regulation elicits the production of ENOA1,2 autoantibodies. • HLA-DRB1*08 allele is more frequent in PDAC patients with autoantibodies. • P-ENOA peptide binds HLA-DR8 antigen and activates specific CD4+ T cell clones.</description><subject>Alleles</subject><subject>Allergy and Immunology</subject><subject>Alpha-enolase (ENOA)</subject><subject>Autoantibodies</subject><subject>Autoantibodies - immunology</subject><subject>Biomarkers, Tumor - chemistry</subject><subject>Biomarkers, Tumor - immunology</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Pancreatic Ductal - genetics</subject><subject>Carcinoma, Pancreatic Ductal - immunology</subject><subject>Carcinoma, Pancreatic Ductal - metabolism</subject><subject>Case-Control Studies</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - immunology</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Gene Frequency</subject><subject>HLA-DR</subject><subject>HLA-DR Serological Subtypes - genetics</subject><subject>HLA-DR Serological Subtypes - immunology</subject><subject>HLA-DR Serological Subtypes - metabolism</subject><subject>HLA-DRB1 Chains - genetics</subject><subject>Humans</subject><subject>Ligands</subject><subject>Lymphocyte Activation - immunology</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Pancreatic Neoplasms - immunology</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Peptides - immunology</subject><subject>Phosphopyruvate Hydratase - chemistry</subject><subject>Phosphopyruvate Hydratase - immunology</subject><subject>Phosphopyruvate Hydratase - metabolism</subject><subject>Phosphorylation</subject><subject>Protein Interaction Domains and Motifs</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Tumor Suppressor Proteins - chemistry</subject><subject>Tumor Suppressor Proteins - immunology</subject><subject>Tumor Suppressor Proteins - metabolism</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9u1DAQxi0EokvhCZBQjlwSxnbidQ4gVeVPkVYCQTlbXnvS9ZK1g-1U2mfgpXHY0gMXONke_T5_o_mGkOcUGgpUvNo37jBibhjQrgHRAMgHZEXluq-ha9lDsipUV7N2Lc_Ik5T2UEDe8sfkjAnohWR0RX5-3oU07UI8jjqjrfQ47XSNPow6YeW8nQ2mSs85aJ_dNlhXns5XV5uL-u0XWU3am4g6O1OZcsVYKtmhz0XkbZWju7nBmO75iKnUzGJ1XRscx0qb7G6LJvin5NGgx4TP7s5z8u39u-vLq3rz6cPHy4tNbdqe5Vpz5IYLAYORg-ZSUs5MN1igmvaMsZ6jhK01DMCAQcq01Mz21GpNbdcKfk5env6dYvgxl4bUwaWlF-0xzEnRNfRUCMnl_6AMZM97VlB-Qk0MKUUc1BTdQcejoqCWwNRe_Q5MLYEpEKoEVlQv7gzm7QHtveZPQgV4fQKwTOTWYVTJlPkatC6iycoG9w-DN3_pzei8M3r8jkdM-zBHX4atqEpMgfq67MyyMrQr60Lbjv8CeRa9vw</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Capello, Michela</creator><creator>Caorsi, Cristiana</creator><creator>Bogantes Hernandez, Pablo Josè</creator><creator>Dametto, Ennia</creator><creator>Bertinetto, Francesca Eleonora</creator><creator>Magistroni, Paola</creator><creator>Rendine, Sabina</creator><creator>Amoroso, Antonio</creator><creator>Novelli, Francesco</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150901</creationdate><title>Phosphorylated alpha-enolase induces autoantibodies in HLA-DR8 pancreatic cancer patients and triggers HLA-DR8 restricted T-cell activation</title><author>Capello, Michela ; Caorsi, Cristiana ; Bogantes Hernandez, Pablo Josè ; Dametto, Ennia ; Bertinetto, Francesca Eleonora ; Magistroni, Paola ; Rendine, Sabina ; Amoroso, Antonio ; Novelli, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-a3e3c3660fc8fa388132c5fd01a1922293e80bdc200c0ce12a8a2d91daa1d5463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alleles</topic><topic>Allergy and Immunology</topic><topic>Alpha-enolase (ENOA)</topic><topic>Autoantibodies</topic><topic>Autoantibodies - immunology</topic><topic>Biomarkers, Tumor - chemistry</topic><topic>Biomarkers, Tumor - immunology</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Pancreatic Ductal - genetics</topic><topic>Carcinoma, Pancreatic Ductal - immunology</topic><topic>Carcinoma, Pancreatic Ductal - metabolism</topic><topic>Case-Control Studies</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - immunology</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Gene Frequency</topic><topic>HLA-DR</topic><topic>HLA-DR Serological Subtypes - genetics</topic><topic>HLA-DR Serological Subtypes - immunology</topic><topic>HLA-DR Serological Subtypes - metabolism</topic><topic>HLA-DRB1 Chains - genetics</topic><topic>Humans</topic><topic>Ligands</topic><topic>Lymphocyte Activation - immunology</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - genetics</topic><topic>Pancreatic Neoplasms - immunology</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Peptides - immunology</topic><topic>Phosphopyruvate Hydratase - chemistry</topic><topic>Phosphopyruvate Hydratase - immunology</topic><topic>Phosphopyruvate Hydratase - metabolism</topic><topic>Phosphorylation</topic><topic>Protein Interaction Domains and Motifs</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Tumor Suppressor Proteins - chemistry</topic><topic>Tumor Suppressor Proteins - immunology</topic><topic>Tumor Suppressor Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capello, Michela</creatorcontrib><creatorcontrib>Caorsi, Cristiana</creatorcontrib><creatorcontrib>Bogantes Hernandez, Pablo Josè</creatorcontrib><creatorcontrib>Dametto, Ennia</creatorcontrib><creatorcontrib>Bertinetto, Francesca Eleonora</creatorcontrib><creatorcontrib>Magistroni, Paola</creatorcontrib><creatorcontrib>Rendine, Sabina</creatorcontrib><creatorcontrib>Amoroso, Antonio</creatorcontrib><creatorcontrib>Novelli, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - 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| subjects | Alleles Allergy and Immunology Alpha-enolase (ENOA) Autoantibodies Autoantibodies - immunology Biomarkers, Tumor - chemistry Biomarkers, Tumor - immunology Biomarkers, Tumor - metabolism Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - metabolism Case-Control Studies DNA-Binding Proteins - chemistry DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Gene Frequency HLA-DR HLA-DR Serological Subtypes - genetics HLA-DR Serological Subtypes - immunology HLA-DR Serological Subtypes - metabolism HLA-DRB1 Chains - genetics Humans Ligands Lymphocyte Activation - immunology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Peptides - immunology Phosphopyruvate Hydratase - chemistry Phosphopyruvate Hydratase - immunology Phosphopyruvate Hydratase - metabolism Phosphorylation Protein Interaction Domains and Motifs T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Suppressor Proteins - chemistry Tumor Suppressor Proteins - immunology Tumor Suppressor Proteins - metabolism |
| title | Phosphorylated alpha-enolase induces autoantibodies in HLA-DR8 pancreatic cancer patients and triggers HLA-DR8 restricted T-cell activation |
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