Phosphorylated alpha-enolase induces autoantibodies in HLA-DR8 pancreatic cancer patients and triggers HLA-DR8 restricted T-cell activation

Highlights • In pancreatic ductal adenocarcinoma the glycolytic enzyme ENOA is upregulated. • Up-regulation elicits the production of ENOA1,2 autoantibodies. • HLA-DRB1*08 allele is more frequent in PDAC patients with autoantibodies. • P-ENOA peptide binds HLA-DR8 antigen and activates specific CD4+...

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Veröffentlicht in:	Immunology letters 2015-09, Vol.167 (1), p.11-16
Hauptverfasser:	Capello, Michela, Caorsi, Cristiana, Bogantes Hernandez, Pablo Josè, Dametto, Ennia, Bertinetto, Francesca Eleonora, Magistroni, Paola, Rendine, Sabina, Amoroso, Antonio, Novelli, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Allergy and Immunology Alpha-enolase (ENOA) Autoantibodies Autoantibodies - immunology Biomarkers, Tumor - chemistry Biomarkers, Tumor - immunology Biomarkers, Tumor - metabolism Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - metabolism Case-Control Studies DNA-Binding Proteins - chemistry DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Gene Frequency HLA-DR HLA-DR Serological Subtypes - genetics HLA-DR Serological Subtypes - immunology HLA-DR Serological Subtypes - metabolism HLA-DRB1 Chains - genetics Humans Ligands Lymphocyte Activation - immunology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - metabolism Peptides - immunology Phosphopyruvate Hydratase - chemistry Phosphopyruvate Hydratase - immunology Phosphopyruvate Hydratase - metabolism Phosphorylation Protein Interaction Domains and Motifs T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Suppressor Proteins - chemistry Tumor Suppressor Proteins - immunology Tumor Suppressor Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights • In pancreatic ductal adenocarcinoma the glycolytic enzyme ENOA is upregulated. • Up-regulation elicits the production of ENOA1,2 autoantibodies. • HLA-DRB1*08 allele is more frequent in PDAC patients with autoantibodies. • P-ENOA peptide binds HLA-DR8 antigen and activates specific CD4+ T cell clones.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.06.008