A natural diarylheptanoid promotes neuronal differentiation via activating ERK and PI3K-Akt dependent pathways

Highlights • Three natural diarylheptanoids possessed neurogenic and neuritogenic activities. • Cpd 1 promoted differentiation of neuroblastoma cells and hippocampal neurons. • Cpd 1 promoted differentiation/maturation of adult-born dentate neural progenitors. • Pro-differentiation activity of Cpd 1...

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Veröffentlicht in:	Neuroscience 2015-09, Vol.303, p.389-401
Hauptverfasser:	Tang, G, Dong, X, Huang, X, Huang, X.-J, Liu, H, Wang, Y, Ye, W.-C, Shi, L
Format:	Artikel
Sprache:	eng
Schlagworte:	adult neurogenesis Alpinia Animals Apoptosis - drug effects Caspase 3 - metabolism Cell Differentiation - drug effects Cells, Cultured dentate gyrus Diarylheptanoids - chemistry Diarylheptanoids - pharmacology Embryo, Mammalian Enzyme Inhibitors - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Hippocampus - cytology Male Mice Mice, Inbred C57BL natural product Nerve Tissue Proteins - metabolism neurite outgrowth Neurites - drug effects Neuroblastoma - pathology Neurology neuronal differentiation neuronal polarization Neurons - drug effects Phosphatidylinositol 3-Kinases - metabolism Rats Signal Transduction - drug effects Signal Transduction - physiology Time Factors Tretinoin - pharmacology
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Zusammenfassung:	Highlights • Three natural diarylheptanoids possessed neurogenic and neuritogenic activities. • Cpd 1 promoted differentiation of neuroblastoma cells and hippocampal neurons. • Cpd 1 promoted differentiation/maturation of adult-born dentate neural progenitors. • Pro-differentiation activity of Cpd 1 was dependent on ERK and PI3K-Akt pathways.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.07.019