The role of shed placental DNA in the systemic inflammatory syndrome of preeclampsia

Preeclampsia is a syndrome occurring only in pregnancy characterized by systemic maternal inflammation and associated with the presence of the placenta. How these 2 aspects of the disease are linked has been the subject of numerous theories and ideas. Recently, there has been increasing interest in...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2015-09, Vol.213 (3), p.268-277
Hauptverfasser:	Hartley, James D.R., BA, Ferguson, Brian J., PhD, Moffett, Ashley, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell-Derived Microparticles - immunology Cell-Derived Microparticles - metabolism Cytokines - immunology Cytokines - metabolism DNA - immunology DNA - metabolism Female Humans Hypoxia - immunology Hypoxia - metabolism inflammation Leptin - immunology Leptin - metabolism Obstetrics and Gynecology Placenta - blood supply Placenta - immunology Placenta - metabolism placental DNA Pre-Eclampsia - immunology Pre-Eclampsia - metabolism preeclampsia Pregnancy Systemic Inflammatory Response Syndrome - immunology Systemic Inflammatory Response Syndrome - metabolism Trophoblasts - cytology Vascular Endothelial Growth Factor Receptor-1 - metabolism
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Beschreibung
Zusammenfassung:	Preeclampsia is a syndrome occurring only in pregnancy characterized by systemic maternal inflammation and associated with the presence of the placenta. How these 2 aspects of the disease are linked has been the subject of numerous theories and ideas. Recently, there has been increasing interest in DNA shed from the placenta into the maternal circulation as a potential agent initiating the inflammatory response. This review will discuss the current evidence and future directions for placental DNA as the linking factor in preeclampsia in the context of other hypotheses.
ISSN:	0002-9378 1097-6868
DOI:	10.1016/j.ajog.2015.03.026