Iron(III)-Selective Chelation-Enhanced Fluorescence Sensing for In Vivo Imaging Applications

A “turn‐on” pattern Fe3+‐selective fluorescent sensor was synthesized and characterized that showed high fluorescence discrimination of Fe3+ over Fe2+ and other tested ions. With a 62‐fold fluorescence enhancement towards Fe3+, the probe was employed to detect Fe3+ in vivo in HeLa cells and Caenorha...

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Veröffentlicht in:Chemistry, an Asian journal an Asian journal, 2015-09, Vol.10 (9), p.1898-1902
Hauptverfasser: Guo, Lin E., Liu, Xin Yi, Wang, Huan, Chen, Qiu Ling, Wang, Guang Ke, Luo, Kaijun, Mi, Qi Li, Zhou, Ying, Zhang, Jun Feng
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Sprache:eng
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Zusammenfassung:A “turn‐on” pattern Fe3+‐selective fluorescent sensor was synthesized and characterized that showed high fluorescence discrimination of Fe3+ over Fe2+ and other tested ions. With a 62‐fold fluorescence enhancement towards Fe3+, the probe was employed to detect Fe3+ in vivo in HeLa cells and Caenorhabditis elegans, and it was also successfully used to elucidate Fe3+ enrichment and exchange infected by innexin3 (Inx3) in hemichannel‐closed Sf9 cells. Into the light: A “turn‐on” pattern Fe3+‐selective fluorescent sensor has been synthesized and characterized that showed high fluorescence discrimination of Fe3+ over Fe2+ and other tested ions. With a 62‐fold fluorescence enhancement towards Fe3+, the probe was employed to detect Fe3+ in vivo in HeLa cells and Caenorhabditis elegans, and it was also successfully used to elucidate Fe3+ enrichment and exchange infected by innexin3 (Inx3) in hemichannel‐closed Sf9 cells.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201500415