Skin microvascular endothelial function as a biomarker in cardiovascular diseases?

Skin microvascular endothelial function is impaired in many cardiovascular diseases, and could be therefore considered as a representative vascular bed. However, today, available evidence allows considering skin microvascular endothelial function neither as a diagnostic biomarker nor as a prognostic...

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Veröffentlicht in:	Pharmacological reports 2015-08, Vol.67 (4), p.803-810
Hauptverfasser:	Hellmann, Marcin, Roustit, Matthieu, Cracowski, Jean-Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiovascular Diseases - diagnosis Cardiovascular Diseases - physiopathology Case-Control Studies Drug Safety and Pharmacovigilance Endothelium Endothelium, Vascular - pathology Endothelium, Vascular - physiology Humans Laser Doppler Laser speckle contrast imaging Laser-Doppler Flowmetry - methods Microvessels - pathology Pharmacotherapy Pharmacy Randomized Controlled Trials as Topic Reactivity tests Review Article Skin - blood supply Skin - pathology Skin microcirculation Vasodilation - physiology
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Beschreibung
Zusammenfassung:	Skin microvascular endothelial function is impaired in many cardiovascular diseases, and could be therefore considered as a representative vascular bed. However, today, available evidence allows considering skin microvascular endothelial function neither as a diagnostic biomarker nor as a prognostic biomarker in cardiovascular diseases. Large follow-up studies using standardized methods should now be conducted to assess the potential predictive value of skin microvascular function in cardiovascular diseases.
ISSN:	1734-1140 2299-5684
DOI:	10.1016/j.pharep.2015.05.008