Reversible Dementia: Two Nursing Home Patients With Voltage-Gated Potassium Channel Antibody-Associated Limbic Encephalitis

Abstract Voltage-gated potassium channel antibody-associated limbic encephalitis (VGKC-LE) is a rare disease that is a diagnostic and therapeutic challenge for medical practitioners. Two patients with VGKC-LE, both developing dementia are presented. Following treatment, both patients showed remarkab...

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Veröffentlicht in:	Journal of the American Medical Directors Association 2015-09, Vol.16 (9), p.790-794
Hauptverfasser:	Reintjes, Wesley, MD, Romijn, Marloes D.M., MD, Hollander, Daan, MD, PhD, ter Bruggen, Jan P., MD, PhD, van Marum, Rob J., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Delayed Diagnosis dementia Dementia - etiology Female Humans Internal Medicine Limbic encephalitis Limbic Encephalitis - complications Limbic Encephalitis - diagnosis Limbic Encephalitis - therapy Male Medical Education Neuropsychological Tests Nursing Homes Potassium Channels, Voltage-Gated VGKC
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Zusammenfassung:	Abstract Voltage-gated potassium channel antibody-associated limbic encephalitis (VGKC-LE) is a rare disease that is a diagnostic and therapeutic challenge for medical practitioners. Two patients with VGKC-LE, both developing dementia are presented. Following treatment, both patients showed remarkable cognitive and functional improvement enabling them to leave the psychogeriatric nursing homes they both were admitted to. Patients with VGKC-LE can have a major cognitive and functional improvement even after a diagnostic delay of more than 1 year. Medical practitioners who treat patients with unexplained cognitive decline, epileptic seizures, or psychiatric symptoms should be aware of LE as an underlying rare cause.
ISSN:	1525-8610 1538-9375
DOI:	10.1016/j.jamda.2015.06.008