Agouti-related peptide–expressing neurons are mandatory for feeding

Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate th...

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Veröffentlicht in:	Nature neuroscience 2005-10, Vol.8 (10), p.1289-1291
Hauptverfasser:	Gropp, Eva, Shanabrough, Marya, Borok, Erzsebet, Xu, Allison W, Janoschek, Ruth, Buch, Thorsten, Plum, Leona, Balthasar, Nina, Hampel, Brigitte, Waisman, Ari, Barsh, Gregory S, Horvath, Tamas L, Brüning, Jens C
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti-Related Protein Animal feeding and feeds Animal Genetics and Genomics Animals Anorexia - metabolism Arcuate Nucleus of Hypothalamus - cytology Behavioral Sciences beta-Galactosidase - biosynthesis Biological Techniques Biomedical and Life Sciences Biomedicine Body Weight - drug effects Body Weight - physiology brief-communication Cell Count - methods Diphtheria Toxin - pharmacology Eating - drug effects Feeding Behavior - physiology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Intercellular Signaling Peptides and Proteins Mice Mice, Knockout Neurobiology Neurons Neurons - drug effects Neurons - metabolism Neuropeptide Y - genetics Neuropeptide Y - metabolism Neuropeptides Neurosciences Physiological aspects Pro-Opiomelanocortin - deficiency Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Proteins - genetics Proteins - metabolism Time Factors
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Beschreibung
Zusammenfassung:	Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn1548