Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2

A series of indole-O-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats. A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 ce...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-03, Vol.16 (6), p.1696-1701
Hauptverfasser:	Zhang, Xiaoyan, Urbanski, Maud, Patel, Mona, Cox, Geoffrey G., Zeck, Roxanne E., Bian, Haiyan, Conway, Bruce R., Beavers, Mary Pat, Rybczynski, Philip J., Demarest, Keith T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diabetes Mellitus, Experimental - urine Glucose - metabolism Glucosides Glucosides - chemical synthesis Glucosides - chemistry Glucosides - pharmacology Indoles - chemistry Medical sciences Miscellaneous Molecular Structure Pharmacology. Drug treatments Rats Rats, Zucker SGLT Sodium-Glucose Transporter 1 - antagonists & inhibitors Sodium-Glucose Transporter 2 - antagonists & inhibitors
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Zusammenfassung:	A series of indole-O-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats. A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.12.006