Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents

The potent in vitro anti-trypanosomal activity of alkyl-linked bis tetrahydro (2 H) 1,3,5 thiadiazine 2-thiones (THTT) I and II is reported. The effect of several alkyl-linked bis tetrahydro-(2 H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC 50 values ranging between 0.3 and 4 μM for the most active compounds.