Natural prevalence of resistance-associated variants in hepatitis C virus NS5A in genotype 3a-infected people who inject drugs in Germany

Natural prevalence of resistance-associated variants in hepatitis C virus NS5A in genotype 3a-infected people who inject drugs in Germany

Highlights • Prevalence of NS5A resistance-associated variants in genotype 3a is largely unknown. • The prevalence was evaluated in 110 PWIDs living in Germany. • A protocol for successful amplification of 98.2% of GT3a samples was established. • 7.2% of treatment-naive PWIDs have resistance-associa...

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Veröffentlicht in:Journal of clinical virology 2015-09, Vol.70, p.43-45
Hauptverfasser: Walker, Andreas, Siemann, Holger, Groten, Svenja, Ross, R. Stefan, Scherbaum, Norbert, Timm, Jörg
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Antiviral treatment
Drug Resistance, Viral
Drug Users
Female
Genetic Variation
Genotype
Genotype 3a
Germany - epidemiology
Hepacivirus - classification
Hepacivirus - drug effects
Hepacivirus - genetics
Hepatitis C - epidemiology
Hepatitis C - virology
Hepatitis C virus
Humans
Infectious Disease
Male
NS5A
Phylogeny
Prevalence
Public Health Surveillance
Sequence Analysis, DNA
Viral Nonstructural Proteins - genetics
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Zusammenfassung:Highlights • Prevalence of NS5A resistance-associated variants in genotype 3a is largely unknown. • The prevalence was evaluated in 110 PWIDs living in Germany. • A protocol for successful amplification of 98.2% of GT3a samples was established. • 7.2% of treatment-naive PWIDs have resistance-associated substitutions in NS5A.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2015.07.008