Obstructive sleep apnea exacerbates airway inflammation in patients with chronic obstructive pulmonary disease

Highlights • We compared the levels of airway inflammation between overlap syndrome and COPD. • Levels of neutrophils, TNFα, and IL-8 were higher in patients with overlap syndrome. • The percentage of neutrophils was associated with the TNFα concentration and IL-8 levels. • TNFα levels were signific...

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Veröffentlicht in:	Sleep medicine 2015-09, Vol.16 (9), p.1123-1130
Hauptverfasser:	Wang, Yeya, Hu, Ke, Liu, Kun, Li, Ze, Yang, Jun, Dong, Yan, Nie, Meiling, Chen, Junwen, Ruan, Yushu, Kang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Airway inflammation Bronchoalveolar Lavage Fluid C-Reactive Protein - metabolism Chronic obstructive pulmonary disease Continuous Positive Airway Pressure Female Humans Interleukin-8 - metabolism Male Middle Aged Neurology Obstructive sleep apnea Prospective Studies Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - pathology Pulmonary Disease, Chronic Obstructive - therapy Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - pathology Sleep Apnea, Obstructive - therapy Sleep Medicine Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Highlights • We compared the levels of airway inflammation between overlap syndrome and COPD. • Levels of neutrophils, TNFα, and IL-8 were higher in patients with overlap syndrome. • The percentage of neutrophils was associated with the TNFα concentration and IL-8 levels. • TNFα levels were significantly correlated with the percentage of nighttime spent with oxygen saturation
ISSN:	1389-9457 1878-5506
DOI:	10.1016/j.sleep.2015.04.019