Evaluation of circulating markers of hepatic apoptosis and inflammation in obese children with and without obstructive sleep apnea

Highlights • Circulating markers of hepatocyte apoptosis were significantly altered in children with obstructive sleep apnea (OSA). • Levels of soluble CD163, a marker of macrophage activation, increased significantly in children with OSA and improved after OSA treatment. • These findings indicate t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Sleep medicine 2015-09, Vol.16 (9), p.1031-1035
Hauptverfasser:	Alkhouri, Naim, Kheirandish-Gozal, Leila, Matloob, Ammar, Alonso-Álvarez, María Luz, Khalyfa, Abdelnaby, Terán-Santos, Joaquin, Okwu, Vera, Lopez, Rocio, Gileles-Hillel, Alex, Dweik, Raed, Gozal, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - blood Antigens, Differentiation, Myelomonocytic - blood Apoptosis Apoptosis - physiology Biomarkers - blood Case-Control Studies Child Fas Ligand Protein - blood fas Receptor - blood Female Hepatocytes - pathology Humans Inflammation Keratin-18 - blood Kupffer Cells - pathology Macrophage Activation - physiology Male Neurology Nonalcoholic fatty liver disease Obesity - blood Obesity - complications Obesity - pathology Obstructive sleep apnea Receptors, Cell Surface - blood Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - pathology Sleep Medicine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Circulating markers of hepatocyte apoptosis were significantly altered in children with obstructive sleep apnea (OSA). • Levels of soluble CD163, a marker of macrophage activation, increased significantly in children with OSA and improved after OSA treatment. • These findings indicate that children with OSA have increased apoptotic and inflammatory pressures.
ISSN:	1389-9457 1878-5506
DOI:	10.1016/j.sleep.2015.05.002