Imbalance of Pro- and Anti-Inflammatory Cytokines in Patients With cHL Persists Despite Treatment Compared With Control Subjects

Micro-Abstract To evaluate the importance of immune alterations that contribute for the escape of HRS neoplastic cells, we analysed serum levels of cytokines in 29 pacients with cHL before and after treatment and compared with healthy subjects. At diagnosis, higher levels of IL-6, IL-10, TNF-α and sCD25 were observed when compared with healthy subjects. After treatment, levels of IL-6, IL-10 and sCD25 had a important reduction but not to normal levels. Elevated levels of IL-6 were correlated with higher IPS, elevated levels of sCD25 with low serum albumin and elevated leveles of IFN-γ with B symptoms.