Au-Catalyzed Pentannulation Reaction of Propargylic Esters Occurring at C(sp3)–H Site

A gold-catalyzed cascade cyclization reaction of easily accessible propargylic esters to cyclopentenones has been developed. This transformation features an unprecedented pentannulation reaction of propargylic esters which occurs at an unactivated C­(sp3)–H site to efficiently produce functionalized...

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Veröffentlicht in:Organic letters 2015-08, Vol.17 (16), p.4062-4065
Hauptverfasser: Kazem Shiroodi, Roohollah, Sugawara, Masumi, Ratushnyy, Maxim, Yarbrough, Douglas C, Wink, Donald J, Gevorgyan, Vladimir
Format: Artikel
Sprache:eng
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Zusammenfassung:A gold-catalyzed cascade cyclization reaction of easily accessible propargylic esters to cyclopentenones has been developed. This transformation features an unprecedented pentannulation reaction of propargylic esters which occurs at an unactivated C­(sp3)–H site to efficiently produce functionalized mono-, bis-, and tricyclic cyclopentenones.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b01983