Cu-mediated direct regioselective C-2 chlorination of indoles

Cu-mediated direct regioselective C-2 chlorination of indoles

Cu-mediated C-2 chlorination of indoles was accomplished with copper(ii) chloride through the use of a directing pyrimidyl protection group. A highly regioselective manner can be achieved on a range of indole substrates with excellent functional group tolerance.

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Veröffentlicht in:Organic & biomolecular chemistry 2015-09, Vol.13 (34), p.9000-9004
Hauptverfasser: Zhao, Jing, Cheng, Xiuzhi, Le, Jun, Yang, Wei, Xue, Fengtian, Zhang, Xuan, Jiang, Chao
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Copper - chemistry
Halogenation
Indoles - chemistry
Molecular Structure
Stereoisomerism
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Zusammenfassung:Cu-mediated C-2 chlorination of indoles was accomplished with copper(ii) chloride through the use of a directing pyrimidyl protection group. A highly regioselective manner can be achieved on a range of indole substrates with excellent functional group tolerance.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob01228g