Tissue specific regulation of transforming growth factor beta by omega-3 lipid-rich krill oil in autoimmune murine lupus

We have previously reported that hybrid New Zealand female mice [(NZBxNZW) F 1 or B W ) fed a diet enriched in ω-3 lipid-rich fish oil vs. ω-6 lipid-rich corn oil show delayed development of autoimmune lupus nephritis and longer life span. The present study was carried out to explore the possible beneficial effects of oil from Antarctic krill ( Euphausia superba) as an alternative source of ω-3 lipids. Weanling B W mice were fed a nutritionally adequate semipurified diet supplemented with either 10% (wt/wt) krill oil (KO) or corn oil (CO). Cross-sectional studies were carried out on kidneys and spleens at 3.5 and 6.5 months of age. Our results indicate that KO prolonged life span (CO, 266.7 days ± 12.5; KO, 330.2 days ± 19.2; P