FOXF2 suppresses the FOXC2-mediated epithelial–mesenchymal transition and multidrug resistance of basal-like breast cancer

Highlights • FOXF2 transcriptionally inhibiting FOXC2 expression in basal-like breast cancer (BLBC). • FOXF2 suppresses the FOXC2-mediated EMT, aggressive property and multidrug resistance in BLBC. • The combined FOXF2 and FOXC2 mRNA levels effectively predict prognosis of triple-negative breast can...

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Veröffentlicht in:	Cancer letters 2015-10, Vol.367 (2), p.129-137
Hauptverfasser:	Cai, Jun, Tian, Ai-Xian, Wang, Qing-Shan, Kong, Peng-Zhou, Du, Xin, Li, Xiao-Qing, Feng, Yu-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Basal-like breast cancer Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer therapies Chemotherapy Conflicts of interest Disease-Free Survival Dose-Response Relationship, Drug Drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition - drug effects Epithelial–mesenchymal transition Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXC2 FOXF2 Gene expression Gene Expression Regulation, Neoplastic Genotype & phenotype Hematology, Oncology and Palliative Medicine Humans Kaplan-Meier Estimate MCF-7 Cells Medical prognosis Metastasis Patients Phenotype RNA Interference RNA, Messenger - metabolism Roles Signal Transduction - drug effects Stem cells Time Factors Transcription factors Transcription, Genetic Transfection Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumors
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Zusammenfassung:	Highlights • FOXF2 transcriptionally inhibiting FOXC2 expression in basal-like breast cancer (BLBC). • FOXF2 suppresses the FOXC2-mediated EMT, aggressive property and multidrug resistance in BLBC. • The combined FOXF2 and FOXC2 mRNA levels effectively predict prognosis of triple-negative breast cancer patients.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.07.001