High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters

Ductal adenocarcinoma, the most common form of pancreatic cancer in humans, is associated with activation of the K-ras oncogene in ∼90% of cases. In contrast, K-ras mutations are found in

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Bibliographische Detailangaben
Veröffentlicht in:	Carcinogenesis (New York) 1996-02, Vol.17 (2), p.303-309
Hauptverfasser:	Sugio, Kenji, Gazdar, Adi F., Albores-Saavedra, Jorge, Kokkinakis, Demetrius M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Mucinous - chemically induced Adenocarcinoma, Mucinous - genetics Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Carcinoma, Ductal, Breast - chemically induced Carcinoma, Ductal, Breast - genetics Cricetinae Experimental digestive system and abdominal tumors Female Genes, ras - drug effects Genes, ras - genetics Liver Neoplasms, Experimental - chemically induced Medical sciences Mesocricetus Molecular Sequence Data Mutation Pancreatic Neoplasms - chemically induced Pancreatic Neoplasms - genetics Polymorphism, Restriction Fragment Length Tumors
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Beschreibung
Zusammenfassung:	Ductal adenocarcinoma, the most common form of pancreatic cancer in humans, is associated with activation of the K-ras oncogene in ∼90% of cases. In contrast, K-ras mutations are found in
ISSN:	0143-3334 1460-2180
DOI:	10.1093/carcin/17.2.303