Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother‐to‐infant transmission of hepatitis B virus

The efficacy and safety of maternal tenofovir disoproxil fumarate (TDF) in reducing mother‐to‐infant hepatitis B virus (HBV) transmissions is not clearly understood. We conducted a prospective, multicenter trial and enrolled 118 hepatitis B surface antigen (HBsAg)– and hepatitis B e antigen–positive...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2015-08, Vol.62 (2), p.375-386
Hauptverfasser:	Chen, Huey‐Ling, Lee, Chien‐Nan, Chang, Chin‐Hao, Ni, Yen‐Hsuan, Shyu, Ming‐Kwang, Chen, Shih‐Ming, Hu, Jen‐Jan, Lin, Hans Hsienhong, Zhao, Lu‐Lu, Mu, Shu‐Chi, Lai, Ming‐Wei, Lee, Chyi‐Long, Lin, Hsien‐Ming, Tsai, Ming‐Song, Hsu, Jenn‐Jeih, Chen, Ding‐Shinn, Chan, K. Arnold, Chang, Mei‐Hwei, Hwa, Hsiao‐Lin, Su, Yi‐Ning, Shih, Jin‐Chung, Chao, Kuang‐Han, Wu, Jia‐Feng, Hsu, Hong‐Yuan, Liu, Chun‐Jen, Su, Tung‐Hung, Lin, Chin‐Chuan, Lin, Pei‐Ying, Yang, Wen‐Rong, Yang, Chun‐Kuang, Chang, Yin‐Kuang, Chen, Kuo‐Hu, Lin, Yu‐Hung, Chen, Heng‐Ju, Pan, Hun‐Shan, Lau, Beng‐Huat, Cheng, Po‐Jen, Chang, Yao‐Lung, Chiueh, Ho‐Yen, Wang, Tzu‐Hao, Lo, Liang‐Ming, Hsieh, Chia‐Lin, Cheng, Shao‐Wen, Lin, Lung‐Huang, She, Bo‐Qing, Koh, King‐Jun, Hung, Yi‐Li, Peng, Fu‐Shiang, Lin, Yu‐Cheng, Wu, Tzee‐Chung, Chen, Chih‐Yao, Chen, Chie‐Pein, Huang, Jian‐Pei, Yeung, Chun‐Yan, Lin, Chen‐Ju, Chiu, Wei‐Tsung, Wang, Duo‐Sheng, Lin, Wen‐Terng, Hwang, Kwei‐Shuai, Huang, Ching‐Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Adult Antigens Deoxyribonucleic acid DNA DNA, Viral - analysis Female Follow-Up Studies Gestational Age Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - transmission Hepatology Humans Infant, Newborn Infectious Disease Transmission, Vertical - prevention & control Liver cirrhosis Male Maternal Age Multivariate Analysis Organophosphonates - therapeutic use Patient Selection Pregnancy Pregnancy Complications, Infectious - drug therapy Pregnancy Complications, Infectious - prevention & control Pregnancy Outcome Prospective Studies Reference Values Risk Assessment Taiwan Tenofovir Treatment Outcome Viral Load - drug effects Young Adult
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Zusammenfassung:	The efficacy and safety of maternal tenofovir disoproxil fumarate (TDF) in reducing mother‐to‐infant hepatitis B virus (HBV) transmissions is not clearly understood. We conducted a prospective, multicenter trial and enrolled 118 hepatitis B surface antigen (HBsAg)– and hepatitis B e antigen–positive pregnant women with HBV DNA ≥7.5 log10 IU/mL. The mothers received no medication (control group, n = 56, HBV DNA 8.22 ± 0.39 log10 IU/mL) or TDF 300 mg daily (TDF group, n = 62, HBV DNA 8.18 ± 0.47 log10 IU/mL) from 30‐32 weeks of gestation until 1 month postpartum. Primary outcome was infant HBsAg at 6 months old. At delivery, the TDF group had lower maternal HBV DNA levels (4.29 ± 0.93 versus 8.10 ± 0.56 log10 IU/mL, P
ISSN:	0270-9139 1527-3350
DOI:	10.1002/hep.27837