Long lasting cerebellar alterations after perinatal asphyxia in rats

Highlights • We studied long-term changes in rat cerebellar cortex after perinatal asphyxia (PA). • PA altered thickness and cell density in the molecular and granular layers. • PA caused Purkinje cell layer disorganization. • PA increased abnormal calbindin staining and altered dendrites in Purkinj...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2015-07, Vol.116, p.57-66
Hauptverfasser:	Campanille, Verónica, Saraceno, G. Ezequiel, Rivière, Stéphanie, Logica, Tamara, Kölliker, Rodolfo, Capani, Francisco, Castilla, Rocío
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Asphyxia Neonatorum - metabolism Asphyxia Neonatorum - pathology Calbindins - metabolism Cerebellar cortex Cerebellum Cerebellum - growth & development Cerebellum - metabolism Cerebellum - pathology Disease Models, Animal Glial Fibrillary Acidic Protein - metabolism Hypoxia Male Microtubule-Associated Proteins - metabolism Neuroglia - metabolism Neuroglia - pathology Neurology Neurons - metabolism Neurons - pathology Perinatal asphyxia Rats, Sprague-Dawley Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • We studied long-term changes in rat cerebellar cortex after perinatal asphyxia (PA). • PA altered thickness and cell density in the molecular and granular layers. • PA caused Purkinje cell layer disorganization. • PA increased abnormal calbindin staining and altered dendrites in Purkinje cells. • PA increased GFAP expression in Bergmann cells and in the granular layer.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2015.06.003