Rivaroxaban and intracranial haemorrhage after mild traumatic brain injury: A dangerous combination?

Highlights • Novel anticoagulants such as rivaroxaban are increasingly prescribed. • We retrospectively analyze patients with mild TBI and intracranial haemorrhage. • Rivaroxaban treatment increased mortality and rate of re-haemorrhage. • Lack of specific antidotes may contribute to unfavourable out...

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Veröffentlicht in:	Clinical neurology and neurosurgery 2015-09, Vol.136, p.73-78
Hauptverfasser:	Beynon, Christopher, Potzy, Anna, Sakowitz, Oliver W, Unterberg, Andreas W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anticoagulants Anticoagulants, Factor Xa inhibitors, Haemostasis, Intracerebral haemorrhage Brain Injuries - complications Brain Injuries - surgery Cardiovascular disease Factor Xa Inhibitors - therapeutic use Female Head injury Humans Intracranial Hemorrhage, Traumatic - complications Intracranial Hemorrhage, Traumatic - drug therapy Intracranial Hemorrhages - drug therapy Intracranial Hemorrhages - etiology Male Middle Aged Mortality Neurology Neurosurgery Platelet Aggregation Inhibitors - therapeutic use Retrospective Studies Rivaroxaban - therapeutic use Traumatic brain injury Treatment Outcome
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Zusammenfassung:	Highlights • Novel anticoagulants such as rivaroxaban are increasingly prescribed. • We retrospectively analyze patients with mild TBI and intracranial haemorrhage. • Rivaroxaban treatment increased mortality and rate of re-haemorrhage. • Lack of specific antidotes may contribute to unfavourable outcome.
ISSN:	0303-8467 1872-6968
DOI:	10.1016/j.clineuro.2015.05.035