DNA methylation in bacteria: from the methyl group to the methylome

DNA methylation in bacteria: from the methyl group to the methylome

Highlights • Bacterial genomes contain C5 -methyl-cytosine, N4 -methyl-cytosine, and N6 -methyl-adenine. • Base methylation controls DNA–protein interactions. • DNA methylation plays roles in bacterial virulence. • Methylome analysis may open a new era in bacterial epigenomics.

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Veröffentlicht in:Current opinion in microbiology 2015-06, Vol.25, p.9-16
Hauptverfasser: Sánchez-Romero, María A, Cota, Ignacio, Casadesús, Josep
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria - genetics
DNA Methylation
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Epigenomics
Genome, Bacterial
Pathology
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Beschreibung
Zusammenfassung:Highlights • Bacterial genomes contain C5 -methyl-cytosine, N4 -methyl-cytosine, and N6 -methyl-adenine. • Base methylation controls DNA–protein interactions. • DNA methylation plays roles in bacterial virulence. • Methylome analysis may open a new era in bacterial epigenomics.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2015.03.004