Folates and aging: Role in mild cognitive impairment, dementia and depression
Highlights • Folate deficiency is prevalent in older individuals due to intestinal malabsorption. • Onset and progression of cognitive disorders is associated with a low folate status. • Hyperhomocysteinemia is the most important mechanism underlying this association. • It is unclear if folate suppl...
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| Veröffentlicht in: | Ageing research reviews 2015-07, Vol.22, p.9-19 |
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| container_title | Ageing research reviews |
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| creator | Araújo, João Ricardo Martel, Fátima Borges, Nuno Araújo, João Manuel Keating, Elisa |
| description | Highlights • Folate deficiency is prevalent in older individuals due to intestinal malabsorption. • Onset and progression of cognitive disorders is associated with a low folate status. • Hyperhomocysteinemia is the most important mechanism underlying this association. • It is unclear if folate supplementation improves cognition in older individuals. |
| doi_str_mv | 10.1016/j.arr.2015.04.005 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1568-1637 |
| ispartof | Ageing research reviews, 2015-07, Vol.22, p.9-19 |
| issn | 1568-1637 1872-9649 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Aging - physiology Aging - psychology Brain - metabolism Cognition - drug effects Cognitive Dysfunction - etiology Cognitive Dysfunction - metabolism Cognitive Dysfunction - prevention & control Dementia - etiology Dementia - metabolism Dementia - prevention & control Depression - etiology Depression - metabolism Disease Progression Folic Acid - metabolism Folic Acid - pharmacology Folic Acid Deficiency - complications Folic Acid Deficiency - metabolism Humans Internal Medicine Intestinal Absorption Neurology Vitamin B Complex - metabolism Vitamin B Complex - pharmacology |
| title | Folates and aging: Role in mild cognitive impairment, dementia and depression |
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