Folates and aging: Role in mild cognitive impairment, dementia and depression

Highlights • Folate deficiency is prevalent in older individuals due to intestinal malabsorption. • Onset and progression of cognitive disorders is associated with a low folate status. • Hyperhomocysteinemia is the most important mechanism underlying this association. • It is unclear if folate suppl...

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Veröffentlicht in:	Ageing research reviews 2015-07, Vol.22, p.9-19
Hauptverfasser:	Araújo, João Ricardo, Martel, Fátima, Borges, Nuno, Araújo, João Manuel, Keating, Elisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging - physiology Aging - psychology Brain - metabolism Cognition - drug effects Cognitive Dysfunction - etiology Cognitive Dysfunction - metabolism Cognitive Dysfunction - prevention & control Dementia - etiology Dementia - metabolism Dementia - prevention & control Depression - etiology Depression - metabolism Disease Progression Folic Acid - metabolism Folic Acid - pharmacology Folic Acid Deficiency - complications Folic Acid Deficiency - metabolism Humans Internal Medicine Intestinal Absorption Neurology Vitamin B Complex - metabolism Vitamin B Complex - pharmacology
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Zusammenfassung:	Highlights • Folate deficiency is prevalent in older individuals due to intestinal malabsorption. • Onset and progression of cognitive disorders is associated with a low folate status. • Hyperhomocysteinemia is the most important mechanism underlying this association. • It is unclear if folate supplementation improves cognition in older individuals.
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2015.04.005