Phosphonate monoesters on a thiacalix[4]arene framework as potential inhibitors of protein tyrosine phosphatase 1B

Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2015-09, Vol.13 (33), p.8803-8806
Hauptverfasser:	Trush, Viacheslav V, Kharchenko, Sergiy G, Tanchuk, Vsevolod Yu, Kalchenko, Vitaly I, Vovk, Andriy I
Format:	Artikel
Sprache:	eng
Schlagworte:	Calixarenes - chemistry Calixarenes - pharmacology Catalytic Domain Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Esters - chemistry Esters - pharmacology Humans Inhibitory Concentration 50 Kinetics Models, Molecular Organophosphonates - chemistry Organophosphonates - pharmacology Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism Serum Albumin - metabolism Temperature
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Beschreibung
Zusammenfassung:	Monoester derivatives of thiacalix[4]arene tetrakis(methylphosphonic) acid were found to be capable of inhibiting protein tyrosine phosphatase 1B. In addition, these compounds can strongly bind to human serum albumin.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c5ob01247c