The effect of selective antagonist of H4 receptor JNJ7777120 on nasal symptoms, cough, airway reactivity and inflammation in guinea pigs

Highlights • Allergic rhinitis induced in experimental conditions up-regulates coughing and airway responsiveness via inflammation and neural mechanisms. • JNJ7777120–novel histamine H4 receptor antagonist reduces nasal symptoms, number of coughs and airway inflammation. • JNJ7777120 also reduces airway responsiveness measured in vitro and in vivo. • H4 receptor antagonists are promising class of drugs with potential clinical application in subjects with upper airway diseases and/or cough.