Extinction learning as a moderator of d -cycloserine efficacy for enhancing exposure therapy in posttraumatic stress disorder

Highlights • d -cycloserine (DCS) is thought to enhance extinction learning consolidation. • Indices of extinction learning did not moderate DCS effects in PE for PTSD. • Regardless of drug condition, more extinction learning was related to better outcome. • Future work should elucidate the optimal...

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Veröffentlicht in:	Journal of anxiety disorders 2015-08, Vol.34, p.63-67
Hauptverfasser:	de Kleine, Rianne A, Smits, Jasper A.J, Hendriks, Gert-Jan, Becker, Eni S, van Minnen, Agnes
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Anxiety Agents - therapeutic use Anxiety Disorders - drug therapy Combined Modality Therapy Cycloserine - therapeutic use d-cycloserine Double-Blind Method Extinction learning Extinction, Psychological Fear - psychology Female Humans Implosive Therapy - methods Learning Male Moderation Posttraumatic stress disorder Psychiatry Self Report Stress Disorders, Post-Traumatic - therapy Treatment Outcome
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Zusammenfassung:	Highlights • d -cycloserine (DCS) is thought to enhance extinction learning consolidation. • Indices of extinction learning did not moderate DCS effects in PE for PTSD. • Regardless of drug condition, more extinction learning was related to better outcome. • Future work should elucidate the optimal conditions for DCS enhancement in PTSD.
ISSN:	0887-6185 1873-7897
DOI:	10.1016/j.janxdis.2015.06.005