Synthesis of Pyrroles through Rhodium(III)-Catalyzed Reactions of Allylamines and Alkenes
Pyrrole derivatives are generated in reactions of allylamines with alkenes that are promoted by a Rh(III) catalyst in the presence of AgOAc. This process, which involves chelation assisted C–H bond activation and N-annulation, is applied to a three step synthesis of Zomepirac.
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| Veröffentlicht in: | Organic letters 2015-08, Vol.17 (15), p.3842-3845 |
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| container_end_page | 3845 |
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| container_issue | 15 |
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| container_title | Organic letters |
| container_volume | 17 |
| creator | Kim, Dong-Su Seo, Yong-Sik Jun, Chul-Ho |
| description | Pyrrole derivatives are generated in reactions of allylamines with alkenes that are promoted by a Rh(III) catalyst in the presence of AgOAc. This process, which involves chelation assisted C–H bond activation and N-annulation, is applied to a three step synthesis of Zomepirac. |
| doi_str_mv | 10.1021/acs.orglett.5b01811 |
| format | Article |
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| language | eng |
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| source | ACS Publications |
| title | Synthesis of Pyrroles through Rhodium(III)-Catalyzed Reactions of Allylamines and Alkenes |
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