Synthesis of Pyrroles through Rhodium(III)-Catalyzed Reactions of Allylamines and Alkenes

Synthesis of Pyrroles through Rhodium(III)-Catalyzed Reactions of Allylamines and Alkenes

Pyrrole derivatives are generated in reactions of allylamines with alkenes that are promoted by a Rh­(III) catalyst in the presence of AgOAc. This process, which involves chelation assisted C–H bond activation and N-annulation, is applied to a three step synthesis of Zomepirac.

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Veröffentlicht in:Organic letters 2015-08, Vol.17 (15), p.3842-3845
Hauptverfasser: Kim, Dong-Su, Seo, Yong-Sik, Jun, Chul-Ho
Format: Artikel
Sprache:eng
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Zusammenfassung:Pyrrole derivatives are generated in reactions of allylamines with alkenes that are promoted by a Rh­(III) catalyst in the presence of AgOAc. This process, which involves chelation assisted C–H bond activation and N-annulation, is applied to a three step synthesis of Zomepirac.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b01811