Efficient Palladium-Catalyzed C–H Fluorination of C(sp3)–H Bonds: Synthesis of β‑Fluorinated Carboxylic Acids

Efficient Palladium-Catalyzed C–H Fluorination of C(sp3)–H Bonds: Synthesis of β‑Fluorinated Carboxylic Acids

A novel and facile process for direct fluorination of unactivated C­(sp3)–H bonds at the β position of carboxylic acids was accomplished by a palladium­(II)-catalyzed C–H activation. The addition of Ag2O and pivalic acid was found to be crucial for the success of this transformation. This reaction p...

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Veröffentlicht in:Organic letters 2015-08, Vol.17 (15), p.3798-3801
Hauptverfasser: Zhu, Qihua, Ji, Dezhong, Liang, Tingting, Wang, Xueyan, Xu, Yungen
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel and facile process for direct fluorination of unactivated C­(sp3)–H bonds at the β position of carboxylic acids was accomplished by a palladium­(II)-catalyzed C–H activation. The addition of Ag2O and pivalic acid was found to be crucial for the success of this transformation. This reaction provides a versatile strategy for the synthesis of β-fluorinated carboxylic acids.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b01774