The established and future biomarkers of malignant pleural mesothelioma

Highlights • A review of front line diagnostic, prognostic, predictive mesothelioma biomarkers. • Circulating mesothelin and pleural fluid hyaluronate/N-ERC mesothelin, may be helpful adjuvant diagnostic tools. • Non-coding RNAs, proteomics and hyaluronan may be important future markers. • Tumor gen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer treatment reviews 2015-06, Vol.41 (6), p.486-495
Hauptverfasser:	Panou, V, Vyberg, M, Weinreich, U.M, Meristoudis, C, Falkmer, U.G, Røe, O.D
Format:	Artikel
Sprache:	eng
Schlagworte:	BAP-1 Biomarkers, Tumor - analysis Calbindin 2 - analysis Extracellular Matrix Proteins - analysis Gene-ratio Hematology, Oncology and Palliative Medicine Humans Hyaluronic Acid - analysis Immunohistochemistry Keratin-5 - analysis lncRNA Lung Neoplasms - diagnosis Membrane Glycoproteins - analysis Mesothelin Mesothelioma - diagnosis Mesothelioma, Malignant MicroRNA MicroRNAs - analysis Pleural Neoplasms - diagnosis Tumor Suppressor Proteins - genetics Ubiquitin Thiolesterase - genetics WT1 Proteins - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • A review of front line diagnostic, prognostic, predictive mesothelioma biomarkers. • Circulating mesothelin and pleural fluid hyaluronate/N-ERC mesothelin, may be helpful adjuvant diagnostic tools. • Non-coding RNAs, proteomics and hyaluronan may be important future markers. • Tumor gene-ratio, FISH assay and deformability cytometry emerge as promising tests. • Mutations of the BAP1 gene are novel susceptibility markers for mesothelioma.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2015.05.001