Is androgen receptor targeting an emerging treatment strategy for triple negative breast cancer?

Highlights • Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. • Androgen receptor (AR) affects regulatory molecules and signaling pathways in TNBC. • AR targeting emerges as a promising strategy for treating specific TNBC subtypes.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer treatment reviews 2015-06, Vol.41 (6), p.547-553
Hauptverfasser:	Anestis, Aristomenis, Karamouzis, Michalis V, Dalagiorgou, Georgia, Papavassiliou, Athanasios G
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - therapeutic use Androgen receptor Breast cancer Estrogen receptor Female Hematology, Oncology and Palliative Medicine Humans Receptors, Androgen - physiology Signal Transduction - physiology Triple negative Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - etiology
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Beschreibung
Zusammenfassung:	Highlights • Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. • Androgen receptor (AR) affects regulatory molecules and signaling pathways in TNBC. • AR targeting emerges as a promising strategy for treating specific TNBC subtypes.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2015.04.009