A new saxitoxin analogue from a xanthid crab Atergatis floridus

A novel paralytic toxin was isolated from toxic specimens of a xanthid crab Atergatis floridus inhabiting the Pacific coast of Shikoku Island. Its structure was deduced to be 11-saxitoxinethanoic acid (SEA) based on highperformance liquid chromatography, electrospray ionization mass spectrometry, an...

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Veröffentlicht in:	Toxicon (Oxford) 1995-12, Vol.33 (12), p.1577-1584
Hauptverfasser:	Arakawa, Osamu, Nishio, Sachio, Noguchi, Tamao, Shida, Yasuo, Onoue, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid - metabolism Animals Atergatis floridus Biological and medical sciences Brachyura Chromatography, High Pressure Liquid Fish Venoms - chemistry Fish Venoms - isolation & purification Fish Venoms - metabolism Injections, Intraperitoneal Magnetic Resonance Spectroscopy Marine Mass Spectrometry Medical sciences Mice Plant poisons toxicology Reference Standards Saxitoxin - chemistry Saxitoxin - isolation & purification Saxitoxin - metabolism Toxicology
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Beschreibung
Zusammenfassung:	A novel paralytic toxin was isolated from toxic specimens of a xanthid crab Atergatis floridus inhabiting the Pacific coast of Shikoku Island. Its structure was deduced to be 11-saxitoxinethanoic acid (SEA) based on highperformance liquid chromatography, electrospray ionization mass spectrometry, and 1H and 13C-NMR spectrometries. This acid was assumed to exist as an equilibrium mixture of three tautomers, the main tautomer being the hydrate form of 11β-epimer. SEA showed a specific toxicity of 830 mouse units per μmole on i.p. injection into mice.
ISSN:	0041-0101 1879-3150
DOI:	10.1016/0041-0101(95)00106-9