Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood

Highlights • Prenatal stress increases respiratory instability in adult offspring. • Prenatal stress affects ventilatory responses to hypoxia and hypercapnia. • Prenatal stress induces a basal state of hypertension and enhances the HPA axis response to stress. • Prenatal stress causes a deficit in i...

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Veröffentlicht in:	Psychoneuroendocrinology 2015-10, Vol.60, p.58-74
Hauptverfasser:	Golubeva, Anna V, Crampton, Sean, Desbonnet, Lieve, Edge, Deirdre, O'Sullivan, Orla, Lomasney, Kevin W, Zhdanov, Alexander V, Crispie, Fiona, Moloney, Rachel D, Borre, Yuliya E, Cotter, Paul D, Hyland, Niall P, O’Halloran, Ken D, Dinan, Timothy G, O’Keeffe, Gerard W, Cryan, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Cognition Colon - microbiology Colon - physiopathology Endocrinology & Metabolism Female Gastrointestinal Microbiome Gut microbiota HPA axis Hypothalamo-Hypophyseal System - physiopathology Intestinal innervation Male Maternal stress Motor Activity Pituitary-Adrenal System - physiopathology Pregnancy Prenatal Exposure Delayed Effects - physiopathology Prenatal Exposure Delayed Effects - psychology Psychiatry Rats Rats, Sprague-Dawley Respiratory control Respiratory Mechanics Restraint, Physical RNA, Bacterial - analysis RNA, Ribosomal, 16S - metabolism Social Behavior Stress, Psychological - microbiology Stress, Psychological - physiopathology
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