Sex-specific regulation of NUCB2/nesfatin-1: Differential implication in anxiety in obese men and women

Highlights • NUCB2/nesfatin-1 is involved in the regulation of mood and stress. • NUCB2/nesfatin-1 is differentially implicated in the regulation of anxiety in men and women. • Sex-specific regulation of NUCB2/nesfatin-1 was also shown for perceived stress and depressiveness.

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Bibliographische Detailangaben
Veröffentlicht in:	Psychoneuroendocrinology 2015-10, Vol.60, p.130-137
Hauptverfasser:	Hofmann, Tobias, Elbelt, Ulf, Ahnis, Anne, Rose, Matthias, Klapp, Burghard F, Stengel, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anxiety - genetics Anxiety - psychology Body Mass Index Calcium-Binding Proteins - biosynthesis Calcium-Binding Proteins - genetics Depression - genetics Depression - psychology DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Emotion Endocrinology & Metabolism Female Gut–brain axis Humans Male Middle Aged Mood Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nucleobindin2 Obesity - genetics Obesity - psychology Psychiatry Psychobiology Psychoneuroendocrine Psychosomatic Sex Characteristics Socioeconomic Factors Stress, Psychological - genetics Stress, Psychological - psychology
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Beschreibung
Zusammenfassung:	Highlights • NUCB2/nesfatin-1 is involved in the regulation of mood and stress. • NUCB2/nesfatin-1 is differentially implicated in the regulation of anxiety in men and women. • Sex-specific regulation of NUCB2/nesfatin-1 was also shown for perceived stress and depressiveness.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2015.06.014