Colorectal cancer-derived tumor spheroids retain the characteristics of original tumors

Highlights • Establishment of three dimensional spheroids derived from colorectal cancer tissues. • The spheroids retain molecular and histological characteristics of patient's tumor. • The spheroids maintain stem cell composition for months. • Cetuximab efficacy test reflects the retaining hum...

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Veröffentlicht in:	Cancer letters 2015-10, Vol.367 (1), p.34-42
Hauptverfasser:	Lee, Sun-Hwa, Hong, Jun Hwa, Park, Hwan Ki, Park, Jun Seok, Kim, Bo-Kyung, Lee, Jung-Yi, Jeong, Ji Yun, Yoon, Ghil Suk, Inoue, Masahiro, Choi, Gyu-Seog, Lee, In-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Antibodies, Monoclonal, Humanized - pharmacology Antineoplastic Agents - pharmacology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell adhesion & migration Cell Line, Tumor Cell Proliferation Cetuximab Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Deoxyribonucleic acid DNA DNA Fingerprinting DNA Mutational Analysis Dose-Response Relationship, Drug Drug Resistance, Neoplasm Female Hematology, Oncology and Palliative Medicine Heterografts Humans Immunohistochemistry Male Mice, Inbred BALB C Mice, Nude Middle Aged Mutation Neoplasm Transplantation Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Patients Polymerase chain reaction Protein Kinase Inhibitors - pharmacology Republic of Korea Review boards Software Spheroid cultures Spheroids, Cellular Time Factors Tumor Burden Tumor Cells, Cultured Tumors Xenograft
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Beschreibung
Zusammenfassung:	Highlights • Establishment of three dimensional spheroids derived from colorectal cancer tissues. • The spheroids retain molecular and histological characteristics of patient's tumor. • The spheroids maintain stem cell composition for months. • Cetuximab efficacy test reflects the retaining human genetic mutation. • Providing new platform for the personalized anti-cancer therapeutics.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.06.024