Fibroblast growth factor receptors (FGFRs) localize in different cellular compartments. A splice variant of FGFR-3 localizes to the nucleus

We have raised specific antibodies to the second immunoglobulin-like domain of fibroblast growth factor receptors (FGFRs) and used these to investigate the expression and subcellular localization of FGFR-1, -2, -3, and -4 in breast epithelial cells. All four receptors classes could be detected in br...

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Veröffentlicht in:	The Journal of biological chemistry 1995-12, Vol.270 (51), p.30643-30650
Hauptverfasser:	Johnston, C L, Cox, H C, Gomm, J J, Coombes, R C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Animals Base Sequence Breast - metabolism Breast Neoplasms - metabolism Cell Line Cell Nucleus - metabolism Chlorocebus aethiops Codon DNA Primers Epithelium - metabolism Exons Female Fibroblast Growth Factors - metabolism Fluorescent Antibody Technique Genetic Variation Humans Immune Sera Molecular Sequence Data Polymerase Chain Reaction Protein Structure, Secondary Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases - analysis Receptor Protein-Tyrosine Kinases - biosynthesis Receptor Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 1 Receptor, Fibroblast Growth Factor, Type 2 Receptor, Fibroblast Growth Factor, Type 3 Receptor, Fibroblast Growth Factor, Type 4 Receptors, Fibroblast Growth Factor - analysis Receptors, Fibroblast Growth Factor - biosynthesis Receptors, Fibroblast Growth Factor - metabolism Recombinant Proteins - analysis Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Sequence Deletion Transfection Tumor Cells, Cultured
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